[1]曾纯,陆宇晗,马淑玲,等.复发难治性B细胞淋巴瘤患者95例行嵌合抗原受体T细胞治疗所致不良反应的护理[J].军事护理,2021,38(01):80-83.[doi:10.3969/j.issn.1008-9993.2021.01.021]
 ZENG Chun,LU Yuhan,MA Shuling,et al.Managing the Adverse Reactions of Chimeric Antigen Receptor T Cell Therapy for 95 Patients with Relapsed Refractory B-cell Lymphoma[J].Nursing Journal Of Chinese People's Laberation Army,2021,38(01):80-83.[doi:10.3969/j.issn.1008-9993.2021.01.021]
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复发难治性B细胞淋巴瘤患者95例行嵌合抗原受体T细胞治疗所致不良反应的护理
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《军事护理》[ISSN:2097-1826/CN:31-3186/R]

卷:
38
期数:
2021年01期
页码:
80-83
栏目:
专科护理
出版日期:
2021-01-15

文章信息/Info

Title:
Managing the Adverse Reactions of Chimeric Antigen Receptor T Cell Therapy for 95 Patients with Relapsed Refractory B-cell Lymphoma
文章编号:
1008-9993(2021)01-0080-04
作者:
曾纯1陆宇晗2马淑玲1应志涛1
(1.北京大学肿瘤医院暨北京市肿瘤防治研究所 淋巴肿瘤内科,北京 100142; 2.北京大学肿瘤医院 护理部)
Author(s):
ZENG Chun1LU Yuhan2MA Shuling1YING Zhitao1
(1.Department of Lyphoma,Beijing Cancer Hospital,Beijing Institute for Cancer Research,Beijing 100142,China; 2.Department of Nursing,Beijing Cancer Hospital,Beijing Institute for Cancer Research)
关键词:
复发难治性B细胞淋巴瘤 嵌合抗原受体T细胞 不良反应 护理
Keywords:
relapsed refractory B-cell lymphoma chimeric antigen receptor T cells adverse reactions nursing
分类号:
R473.55
DOI:
10.3969/j.issn.1008-9993.2021.01.021
文献标志码:
A
摘要:
总结95例复发难治性B细胞淋巴瘤患者接受以CD19为靶点的嵌合抗原受体T细胞治疗所致不良反应的护理经验。护理要点包括:密切监测及时发现CAR-T治疗患者生命体征及血液学指标变化; 专科护理评估尽早识别中枢神经系统不良反应; 做好细胞因子释放综合征和CAR-T治疗相关性脑病患者的症状管理以及特殊用药的护理等。本组病例除1例患者因多器官功能衰竭死亡外,其余患者的不良反应均得到有效控制,顺利出院。
Abstract:
This paper summarized the experience of providing care for 95 patients with relapsed refractory B-cell lymphoma who received chimeric antigen receptor T cell therapy targeting CD19 and showed adverse reactions.The key points of nursing care included close monitoring and timely detection of the changes of vital signs and hematological indicators of CAR-T patients,specialized nursing assessment for early identification of adverse reactions of the central nervous system,sound symptom management of those patients with cytokine release syndrome and CAR-T treatment related encephalopathy,and care for special medications.With the exception of one patient who died of multiple organ failure,the adverse reactions of the other patients were effectively controlled and discharged from hospital successfully.

参考文献/References:

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(本文编辑:陈晓英)

备注/Memo

备注/Memo:
【 收稿日期 】 2020-09-26 【 修回日期 】 2020-11-30
【 作者简介 】 曾纯,硕士,主管护师,主要从事肿瘤临床护理
【 通讯作者 】 陆宇晗,电话:010-88196184
更新日期/Last Update: 2021-01-15